The forward, who has just one goal in his last eight appearances for the club, is being carefully managed by his manager as the only senior striker in the squad.
Goalkeeper Lukasz Fabianski has also been left back in London with Alphonse Areola getting another chance to impress between the sticks as he looks to stake a claim for the No1 spot.
Neither Antonio or Fabianski have any injury concerns.
“We chose not to bring him,” Moyes said on Antonio.
“Apart from that, only Lukasz isn’t here. You’re well aware of where we are. We’ll be strong but we know that we’ve got some big games coming up and a really busy schedule.”
West Ham XI: Areola; Coufal, Dawson, Diop, Masuaku; Noble, Soucek; Yarmolenko, Lanzini, Vlasic; Bowen
Subs: Randolph, Cresswell, Zouma, Johnson, Fredericks, Alese, Chesters, Kral, Rice, Benrahma, Fornals, Perkins
Date: Thursday, November 25, 2021. Kick-off is at 5.45pm GMT, live on BT Sport 1.
West Ham squad from: Martin, Randolph, Areola, Diop, Dawson, Zouma, Baptise, Coufal, Johnson, Fredericks, Cresswell, Masuaku, Rice, Soucek, Noble, Kral, Vlasic, Yarmolenko, Fornals, Lanzini, Benrahma, Bowen.
Rested: Fabianski, Antonio.